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Understanding Drysol: A Comprehensive Guide for Hyperhidrosis Management

What is Drysol?

Drysol is a distinctive and highly effective topical antiperspirant specifically designed to combat excessive sweating, a condition medically known as hyperhidrosis. It stands out in its field due to its active ingredient, Aluminum Chloride Hexahydrate (ACH), which boasts a remarkable 98% efficacy in controlling sweat and can reduce sweat volume by up to 30%. This makes Drysol a first-line therapy choice for those suffering from hyperhidrosis, offering relief across various parts of the body like underarms, hands, feet, and even the forehead.

The unique formulation of Drysol, available in different strengths such as Mild (6.25%), Regular (12%), and Extra Strength (20%), caters to varying degrees of hyperhidrosis severity, thus accommodating a wide range of user needs. Notably, Drysol has earned the approval of the Canadian Dermatology Associations’ Skin Health Program, affirming its safety and effectiveness.

Composition: Aluminum Chloride Hexahydrate as the Active Ingredient

Aluminum Chloride Hexahydrate (ACH) is the key component that sets Drysol apart from regular antiperspirants. While most over-the-counter antiperspirants contain aluminum-based active ingredients in concentrations ranging between 12-25%, Drysol’s formulation includes up to 30% of ACH. This higher concentration enables Drysol to effectively block the sweat glands, thereby significantly reducing excessive sweating.

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How to Use Drysol Effectively

Application Instructions

Start by ensuring the skin is completely dry before applying the product. This can be achieved by waiting at least 2 hours after bathing or showering. If necessary, a hair dryer set on a cool setting can be used to dry the skin thoroughly. When applying Drysol, it’s important to cover only the affected area with a thin layer of the product. This is best done at bedtime, as sweat glands are typically less active during the night, allowing the product to work more effectively. After applying, allow Drysol to dry naturally; do not rub it into the skin. In the morning, wash the treated area with soap and water to remove any residue. This routine should be followed until you notice a significant reduction in sweating, after which the frequency of application can be reduced.

Tips for Maximizing Efficacy

  1. Apply at Bedtime: Applying Drysol at night maximizes its effectiveness as the sweat glands are less active, allowing the product to form a deeper blockage in the sweat ducts.
  2. Use Plastic Wrap for Hands/Feet: For those using Drysol on their hands or feet, wrapping the treated area in plastic wrap overnight can enhance the absorption of the product. Cover the plastic wrap with cotton gloves or socks to keep it in place and to prevent the product from rubbing off onto bed linens.
  3. Avoid Irritation: Do not apply Drysol to broken, irritated, or recently shaved or waxed skin, as it can cause significant irritation.
  4. Consistent Use: Consistency is key in the treatment of hyperhidrosis. Regular application as per the prescribed routine is crucial until the desired reduction in sweating is achieved.
  5. Consult with Healthcare Providers: It’s always advisable to consult with a healthcare provider for personalized advice, especially if you experience any irritation or if the sweating does not improve.

Possible Side Effects of Drysol

Common Side Effects

While Drysol is effective in treating hyperhidrosis, like any medication, it can have side effects. Common side effects include:
  • Itching: Users may experience mild to moderate itching at the site of application.
  • Mild Burning: A sensation of burning can occur when Drysol is applied, usually subsiding after a few uses.
  • Prickling: A prickling feeling may be noticed during the initial applications.
  • Irritation: Particularly on sensitive skin areas, Drysol can cause irritation.
  • Skin Dryness: Due to its antiperspirant properties, Drysol can cause dryness of the skin where it is applied.

Serious Side Effects and Precautions

While rare, Drysol can also have more serious side effects. It is crucial to be aware of these and take appropriate precautions:
  • Severe Skin Irritation: If you experience severe burning, redness, or swelling, it is important to discontinue use and consult a healthcare provider.
  • Allergic Reactions: Signs of an allergic reaction can include rash, hives, itching, red or swollen skin, and difficulty breathing or swallowing. Immediate medical attention is necessary in these cases.
  • Staining of Clothes or Skin: Drysol can sometimes stain clothing or even the skin, so care should be taken in its application.
  • Interaction with Other Products: It is recommended not to use other deodorants or antiperspirants while using Drysol, as this can increase skin irritation.
In any case where side effects are severe or persist, consulting a healthcare provider is essential. They can provide guidance on whether to continue using Drysol and suggest alternative treatments if necessary.
drysol side effect

Drysol Variants and Prescription Details

Different Strengths and Forms of Drysol

Drysol is available in various strengths and forms to cater to different levels of hyperhidrosis severity and skin sensitivities:
  1. Drysol Mild (6.25% ACH): This variant is suitable for individuals with mild hyperhidrosis or those with sensitive skin. It’s typically used on areas like the arms, feet, back, and legs.
  2. Drysol Regular (12% ACH): Ideal for moderate cases of hyperhidrosis, this strength is often used on arms, feet, and hands.
  3. Drysol Extra Strength (20% ACH): This is the most potent form of Drysol, designed for the toughest cases of hyperhidrosis. It’s commonly applied to areas like arms, feet, and hands.
Each form of Drysol is tailored to provide effective relief while minimizing skin irritation, allowing users to choose the one that best suits their specific needs.

Prescription Requirements

Drysol’s availability can vary depending on regional regulations. In some areas, Drysol may be available over the counter, while in others, it requires a prescription from a healthcare provider. The prescription requirement is often based on the concentration of the active ingredient, Aluminum Chloride Hexahydrate, with higher concentrations typically needing a prescription. It is important for users to consult with a healthcare provider to determine the most appropriate strength and form of Drysol for their condition. This consultation also provides an opportunity to discuss any potential side effects or interactions with other medications or skin care products.
drysol side effects

Drysol Review: A Hyperhidrosis Sufferer’s Perspective


For individuals with hyperhidrosis, especially in problematic areas like the armpits and scalp, Drysol emerges as a highly effective solution. A Hyperhidrosis Sufferer, reports significant success with Drysol for her underarm sweating, noting a drastic reduction in sweating for up to a week with consistent nightly use. This aligns with the experiences of many who struggle with excessive sweating, highlighting Drysol’s potency in managing symptoms.

Strength and Usage:

Drysol is recognized for its strong formulation. While this contributes to its effectiveness, it also brings a degree of caution in its application. Users like a Hyperhidrosis Sufferer in Facebook find they need to apply a significant amount to achieve desired results, which may be a consideration for those with sensitive skin or looking for a more mild treatment.

Alternatives and Prescription Requirement:

A recurring query among users is the availability of over-the-counter alternatives to Drysol, which typically requires a prescription. The Hyperhidrosis Sufferer inquiry reflects a common desire among hyperhidrosis sufferers for more accessible treatment options, though no specific alternatives were mentioned in the discussion.

Concerns over Staining and Discoloration:

A unique issue raised by Kelli is the discoloration of clothes due to sweating, particularly from the armpits. While she suspects a link to her antiperspirants, including Drysol, there’s no conclusive evidence in the discussion tying Drysol directly to this problem. It remains an area of concern for those experiencing similar issues.

Overall Recommendation:

Drysol is highly recommended for those dealing with severe hyperhidrosis, particularly in the underarm area. Its effectiveness in reducing sweating is well-documented among users like the Hyperhidrosis Sufferer in the below Facebook group. However, individuals should be mindful of its strength and potential side effects, such as skin sensitivity and possible clothing discoloration. As always, consulting a healthcare professional before starting any new treatment is advisable, especially for a condition as complex as hyperhidrosis.

drysol reviews

Alternative Treatments for Hyperhidrosis

While Drysol is a popular choice for treating hyperhidrosis, there are other treatments available for those who might not find relief with topical antiperspirants or who are looking for alternative options.

Oral Medications

Oral medications can be prescribed to manage hyperhidrosis. These often include anticholinergic drugs, which work by blocking neurotransmitters that stimulate sweat production. While effective, they may have side effects such as dry mouth, blurred vision, and urinary retention. It’s important to discuss the potential benefits and risks with a healthcare provider.


Iontophoresis is a non-invasive treatment that involves passing a mild electrical current through water and into the skin. It’s particularly effective for sweating of the hands and feet. The procedure temporarily block the sweat glands, reducing sweating. One recommended device for iontophoresis is the Iontodri machine. The Iontodri machine is designed to be user-friendly and effective, making it a popular choice for those seeking home treatment for hyperhidrosis.

Surgical Options

In severe cases of hyperhidrosis, surgery might be considered. Options include:

  • Endoscopic Thoracic Sympathectomy (ETS): This involves cutting or destroying some of the nerves responsible for excessive sweating. It’s mainly used for sweating of the hands but can have significant side effects, including compensatory sweating (increased sweating in other body areas).
  • Sweat Gland Removal: For localized hyperhidrosis, such as in the underarms, the sweat glands may be surgically removed.

Each of these surgical options comes with its own set of risks and considerations, and they are generally seen as last-resort treatments after other methods have been tried.

In choosing the best treatment for hyperhidrosis, it’s important to consult with a healthcare provider to understand the benefits, risks, and suitability of each option based on individual needs and health conditions.

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